Publication on Multiscale Modelling with Arbor

From Atoms to Neuronal Spikes: A Multiscale Simulation Framework

Article

From the abstract:

Understanding how molecular events in ion channels impact neuronal excitability, as derived from the calculation of the time course of the membrane potentials, can help elucidate the mechanisms of neurological disease-linked mutations and support neuroactive drug design. Here, we propose a multiscale simulation approach which couples molecular simulations with neuronal simulations to predict the variations in membrane potential and neural spikes.